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Products Nrf2 (N-Term) Polyclonal Antibody
| Catalogue number: | 14114 |
| Hosts: | Rabbit |
| Applications: | Flow Cytometry, Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human Nrf2 N-terminal amino acids 18-29 |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | This N-terminal Nrf2 polyclonal antibody detects both poly-ubiquitinated Nrf2 at 90 kDa and native Nrf2 at 67 kDa. Nrf2 is a transcription factor that forms a heterodimer with a small Maf protein and binds to the antioxidant response element in the upstream promoter region of many antioxidative genes. Under normal, unstressed conditions, Nrf2 is sequestered in the cytoplasm where it is bound to and ubiquitinated by Kelch like-ECH-associated protein 1 (Keap1) and cullin 3. Certain inflammatory, environmental, or oxidative stressors disrupt Keap 1 binding and prevent ubiquitination. This leads to a buildup of Nrf2 in the cytoplasm, and subsequent translocation into the nucleus. |
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