NT-1, Recombinant, Human (Neurotrophin 1/B Cell Stimulating Factor 3, BCSF-3)

Human NT-1/BCSF-3 (Neurotrophin-1/B-Cell Stimulating Factor-3) is identi?ed as part of the IL-6 family of cytokines. It is most homologous to cardiotrophin-1 and ciliary neurotrophic factor. NT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-b) and induces tyrosine phosphorylation of these receptors. In vitro, it supports survival of chick embryo motor and sympathetic neurons. In mice, NT-1/BCSF-3 includes serum amyloid A, causes body weight loss and B cell hyperplasia associated with increase in serum IgG and IgM. Recombinant human NT-1/BCSF-3 is a 22.4kD protein containing 199 amino acid residues.\n\nAA Sequence:\nMLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF\n\nEndotoxin:\n(same/less than) 0.1ng/ug (1EU/ug)\n\nBiological Activity:\nNT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0ng/ml. \n\nReconstitution: \nReconsitute with water to a concentration of 0.1-1.0mg/ml. \n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile water and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nCountry of Origin: \nUSA

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