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NTAL, aa27-243, Recombinant, Human (LAT2, Linker for Activation of T Cells Family, Member 2, LAB, Linker for Activation of B-cells, Membrane-associated Adapter Molecule, Non-T-cell Activation Linker, WBS15, WBSCR15, WBSCR5, Williams-Beuren Syndrome Chromo

Cat no: N6000-26D

NTAL, aa27-243, Recombinant, Human (LAT2, Linker for Activation of T Cells Family, Member 2, LAB, Linker for Activation of B-cells, Membrane-associated Adapter Molecule, Non-T-cell Activation Linker, WBS15, WBSCR15, WBSCR5, Williams-Beuren Syndrome Chromo

NTAL (non-T cell activation linker), as known as LAT2, is transmembrane adaptor protein (TRAP) associated with glycolipid-enriched membrane fractions (GEM or lipid rafts). This protein is primarily expressed in spleen and hematopoietic cells, such as B cells, mast cells, NK cells, and monocytes, but not resting T cells. Defects in NTAL may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS). \n\nSource:\nRecombinant corresponding to aa27-243 of human NTAL 6x his tagged, expressed in E.coli. \n\nAA Sequences: \nMGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE\nEDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

N6000-26D

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol.

Purity

~80% (SDS-PAGE).

References

1. Naumann M., et al. (2010) Cell Signal. 22(3):395-403. 2. Gilfillan AM., et al. (2008). Int J Biochem Cell Biol. 39(5): 868-873.

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