NUP98 (Nuclear pore complex protein Nup98 Alternative name(s): 98kD nucleoporin Nucleoporin Nup982.Nuclear pore complex protein Nup96, Nup96)

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of ~50 unique proteins collectively known as nucleoporins. The 98kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186kD precursor protein. This cleavage results in the 98kD nucleoporin as well as a 96kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. \n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested. \n\nRecommended Dilution:\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

143219

Size

100ul

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM NaCl, 0.2% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1

Additional Info

Recognizes endogenous levels of NUP98. Does not cross-react with related proteins. Species Crossreactivity: human

Alternative Names

(Nuclear pore complex protein Nup98 Alternative name(s): 98kD nucleoporin Nucleoporin Nup982.Nuclear pore complex protein Nup96 Alternative name(s): 96kD nucleoporin Nucleoporin Nup96)