Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC50=90nM for Nutlin-3a and 13.6uM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.
Solubility:
DMSO (~20mg/ml)
Molecular Weight:
~581.49
Catalogue number:
N8490-01
Size:
1mg
Form:
Supplied as a white to off-white solid.
Purity:
~98% (HPLC)
References:
1. Vassilev, L.T., et al. (2004). Science 303, 844-848.