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O-Deacetyl-ravidomycin (Antibiotic AY 26623)

O-Deacetyl-ravidomycin (Antibiotic AY 26623)

Cat no: D1773

Supplier: United States Biological
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O-deacetyl-ravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light dependent antitumour activity. Microbial Screening Technologies in-house bioassays detected weak antibacterial and antifungal activity. O-Deacetyl-ravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor. Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, Gilvocarcin V
Catalogue number: D1773
Size: 500ug
Form: Supplied as a yellow solid
Purity: ~95% by HPLC
Alternative names: Antibiotic AY 26623
References: 1. New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al. J. Antibiot. 1998, 51, 1105. 2. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985. 3. Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al. Antimicrob. Agents Chemother. 1986, 29, 861. 4. Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. Rakhit S. et al. Antimicrob. Agents Chemother. 1986, 29, 861.

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