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Oligomycin A

Cat no: O6154

Oligomycin A

Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A is a inhibitor of mitochondrial F1F0-ATPase. Induces apoptosis in a variety of cell types. Makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin exibits a broad biological profile including antifungal, antitumor and nematocidal activities.\n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO.\n\nRelated to: Oligomycin B, Oligomycin C, 21-hydroxyoligomycin A

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SPECIFICATIONS

Catalog Number

O6154

Size

5mg

Purity

>95% by HPLC\n\n

References

1. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. \nMiyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727. \n2. Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. \nNatl Acad. Sci. USA 2001, 98, 1717. \n3. The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. \nFitch M.E. et al. Cell Death Differ. 2000, 7, 338.

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