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Oligomycin A

Cat no: O6154


Supplier: United States Biological
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Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A is a inhibitor of mitochondrial F1F0-ATPase. Induces apoptosis in a variety of cell types. Makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin exibits a broad biological profile including antifungal, antitumor and nematocidal activities. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Oligomycin B, Oligomycin C, 21-hydroxyoligomycin A
Catalogue number: O6154
Size: 5mg
Purity: >95% by HPLC
References: 1. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727. 2. Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. Natl Acad. Sci. USA 2001, 98, 1717. 3. The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al. Cell Death Differ. 2000, 7, 338.

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