Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis.
Related to:
Oligomycin A, Oligomycin C, 21-hydroxyoligomycin A
Solubility:
Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability:
For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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