Oncostatin M, Recombinant, Human (OSM)

Oncostatin M is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cancer cells but augments the growth of normal fibroblasts, AIDS related Kaposi sarcoma cells, and certain other cells. Oncostatin M is a 25.8kD protein containing 227 amino acid residues.\n\nBiological Activity\nUSBio's human Oncostatin M is fully biologically active when compared to standards. The ED50 as determined by the dose dependent stimulation of the proliferation of human TF-1 cells is \n(same/less than) 2ng/ml, corresponding to a specific activity of 5x10e5 units/mg.\n\nResponding Cells (partial list):\nTumor cells, certain other cells\n\nConcentration Range:\nFor most in vitro applications: 0.1-10ng/ml\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume in sterile water and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts