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Orexin A, aa1-33, Cyclized

Cat no: O7500-03B

Orexin A, aa1-33, Cyclized

Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus. Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is a 130aa long peptide with a putative 33aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis. These neuropeptides bind and activate two closely related Orexin receptors- -G-protein coupled receptors (GPCRs) OX1R and OX2R.\n\nSource:\nMouse/rat/human Orexin-A is a 33aa peptide. Full length Orexin-A peptide corresponding to aa1-33 (

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SPECIFICATIONS

Catalog Number

O7500-03B

Size

1mg

Form

Supplied as a lyophilized powder with no additives. Reconstitute with 1ml ddH2O and mix for 15 minutes at RT.

Purity

Purified by HPLC

References

1. Sakurai, T. et al. (1998) Cell, 92, 573-585. 2. DeLecca L et al (1998) PNAS 95, 322-327. 3. Kirchgessner et al (1999) Neuron 24, 941. 4. Dube MG et al (1999) Brian res. 842, 473-477. 5. Jain MR et al (2000) Regulatory Peptides 87, 18-24.

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