Osteoprotegerin, 22-401aa, Recombinant Human (OPG, Osteoclastogenesis Inhibitory Factor, OCIF)

Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF)-related family, is referred to as TNFRSF11B and part of the OPG/receptor activator of NF-?B ligand (RANKL)/receptor activator of NF-?B (RANK) triad. This cytokine that lacks any apparent cell-association motifs and exists as a soluble secreted protein, network regulates the differentiation and activation of osteoclasts and hence the critical balance between bone formation (osteoblasts) and bone resorption (osteoclasts). \n\nRecombinant human osteoprotegerin protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques\n\nEndotoxin Level:\n(same/less than)1.0 EU per 1ug of protein (LAL )\n\nAA sequence:\nADPETFPPKY LHYDEETSHQ LLCDKCPPGT YLKQHCTAKW KTVCAPCPDH YYTDSWHTSD ECLYCSPVCK ELQYVKQECN RTHNRVCECK EGRYLEIEFC\nLKHRSCPPGF GVVQAGTPER NTVCKRCPDG FFSNETSSKA PCRKHTNCSV FGLLLTQKGN ATHDNICSGN SESTQKCGID VTLCEEAFFR FAVPTKFTPN\nWLSVLVDNLP GTKVNAESVE RIKRQHSSQE QTFQLLKLWK HQNKDQDIVK KIIQDIDLCE NSVQRHIGHA NLTFEQLRSL MESLPGKKVG AEDIEKTIKA\nCKPSDQILKL LSLWRIKNGD QDTLKGLMHA LKHSKTYHFP KTVTQSLKKT IRFLHSFTMY KLYQKLFLEM IGNQVQSVKI SCLSGRLVPR GSHHHHHH\n\nStorage and Stability:\nStore at -20 degrees C. Stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

O8065-01E

Size

150ug

Form

Supplied as a liquid in PBS, pH 7.4, 10% glycerol.

Purity

(same/more than)85 % by SDS-PAGE

References

1.Lacey, D.L. et al. (1998) Cell 93:165-76 2. Yasuda H. et al. (1998) PNAS 95:3597-602 3. A. Van Campenhout, Golledge J. (2009) Atherosclerosis 204:321-29