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OX40:Fc, Recombinant, Human (TNFRSF 4, Tumor Necrosis Factor Receptor Superfamily Member 4, CD134)

OX40:Fc, Recombinant, Human (TNFRSF 4, Tumor Necrosis Factor Receptor Superfamily Member 4, CD134)

Cat no: 045123

Supplier: United States Biological
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OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully. Biological Activity: Blocks T cell proliferation induced by CD134L. Sequence: Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 045123
Size: 50ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity: >95% (SDS-PAGE)
Alternative names: TNFRSF 4, Tumor Necrosis Factor Receptor Superfamily Member 4, CD134
Additional info: Binds to human and mouse OX40L.

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