Oxazepam(N)

The benzodiazepines are a group of over 20 structurally related central nervous system depressant drugs, each group varying considerably in their potency and clinical effects. The benzodiazepines are the most widely prescribed sedative/hypnotic drugs due to their wide range of uses (2, 4, 5). They are prescribed to treat anxiety, stress and insomnia. They are also used both as pre-medication and for induction of general anaesthesia. Specific uses include the management of alcohol withdrawal, control of epileptic fits and relief of muscle spasms(6). Benzodiazepines are extensively metabolised by the liver by processes of N-dealkylation and hydroxylation and only trace amounts of the parent compound appear in the urine. Many benzodiazepine metabolites are excreted in urine as glucuronide tracers.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1.25ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

B1075-02D

Size

100ul

Applications

ELISA

Hosts

Sheep

Form

Supplied as a liquid in 20mM phosphate, 150mM sodium chloride, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Simpson D., Braithwaite RA., Jarvie DR., Stewart MJ., WalkerS., Watson IW and Widdop B. Screening for drugs of abuse (II): cannabinoids, lysergic acid diethylamide, buprenorphine, methadone, barbiturates, benzodiazepines and other drugs, Ann Clin Biochem, 1997, 34: 460-497. 2. Beselt RC. Urine Drug Screening by Immunoassay: Interpretation of Results. In: Beselt RC, Advances in Analytical Toxicology, vol 1, chapter 5, 97-102. 5. Wild D. (ed), The Immunoassay Handbook, second edition, Nature Publishing Group, London, Basingstoke, New York, 2001; 790-793. 3. Wolff K, Garretty D and Hay AW. Micro-extraction of commonly abused benzodiazepines for urinary screening by liquid chromatography, Ann Clin Biochem, 1997; 34: 61-67.

Additional Info

Recognizes oxazepam.