P14ARF Antibody

Cat no: 251543

Supplier: ABBIOTEC

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Description
Additional Information

Cyclin-dependent kinase inhibitor 2A (P14ARF) is capable of inducing cell cycle arrest in G1 and G2 phases. P14ARF acts as a tumor suppressor. P14ARF binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. P14ARF also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 comple, Xenopus/Amphibian,es.

Catalogue number:	251543
Reactivities:	Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q8N726
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human P14ARF.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Cyclin-dependent kinase inhibitor 2A, isoform 4; p14ARF; p19ARF; CDKN2A; CDKN2; MLM