p38 MAPK (Phospho-Thr180/Tyr182) Cell-Based Phosphorylation/Translocation Assay Kit

p38 MAPK is activated by phosphorylation at Thr180 and Tyr182 in response to both inflammatory cytokines and stress, making it an important enzyme in diseases like asthma and autoimmunity, as well as in the stress response of the nervous system. Cayman's p38 Cell-Based Phosphorylation/Translocation Assay provides a highly specific phospho-p38 MAPK (phospho-Thr180 and Tyr182) primary antibody together with a DylightTM (product of Thermo Scientific) conjugated secondary antibody in a ready-to-use format. Thrombin, which has been shown by scientists at Cayman's to cause the translocation of phospho-p38 MAPK (phospho-Thr180 and Tyr182) into nuclei, is included as a positive control.

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SPECIFICATIONS

Catalog Number

10010374

Form

1 ea

P Type

Assay Kits|Intracellular Signaling

Weight

0

Storage Temp

-20

Shipping Temp

-20

Additional Info

p38 MAPK is activated by phosphorylation at Thr180 and Tyr182 in response to both inflammatory cytokines and stress, making it an important enzyme in diseases like asthma and autoimmunity, as well as in the stress response of the nervous system. The subcellular location of p38 following stimulation is not well understood. Some evidence suggests that activated p38 translocates from the cytoplasm to the nucleus, whereas other reports indicate that phosphorylated p38 is present in the cytoplasm of stimulated cells. Cayman's p38 Phosphorylation/Translocation Cell-Based Assay Kit provides a highly specific phospho-p38 MAPK (phospho-Thr180 and Tyr182) primary antibody together with a DyLightTM (product of Thermo Fisher Scientific Inc.) conjugated secondary antibody in a ready-to-use format. Thrombin, which has been shown by scientists at Cayman Chemical to cause the translocation of phospho-p38 MAPK (phospho-Thr180 and Tyr182) into nuclei, is included as a positive control.