Home  >  Products  >  P38delta, Active, Recombinant, Human (Active P38delta, P38delta, P38, p38, p38delta, p38d, human P38delta, active kinase, active kinases, recombinant P38delta, recombinant P38d, kinase activity assay, protein kinase)
P38delta, Active, Recombinant, Human (Active P38delta, P38delta, P38, p38, p38delta, p38d, human P38delta, active kinase, active kinases, recombinant P38delta, recombinant P38d, kinase activity assay, protein kinase)

P38delta, Active, Recombinant, Human (Active P38delta, P38delta, P38, p38, p38delta, p38d, human P38delta, active kinase, active kinases, recombinant P38delta, recombinant P38d, kinase activity assay, protein kinase)

Cat no: 167931

Supplier: United States Biological
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Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses, and involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The stress-activated protein kinase 4 (SAPK4), or p38 delta, is a member of the MAPK family that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. Source: Recombinant protein corresponding to human p38delta, expressed in Sf9 insect cells. Molecular Weight: ~71.0kD Biological Activity: 259 nmol phosphate incorporated into MBP protein per minute per mg protein at 30 degrees C for 15 minutes using a final concentration of 50um ATP. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 167931
Size: 5ug
Form: Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity: ~80% (SDS-PAGE)
References: 1. Goedert, M.; Cuenda, A.; Craxton, M.; Jakes, R.; Cohen, P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16: 3563-3571, 1997. 2. Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.

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