PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21)

Antigen: human PAF receptor amino acids 260-269 . Host: mouse, 11A4 clone 21 . Cross Reactivity: (+) human, bovine, and porcine PAF receptor . Application(s): FC, ICC; does not work for WB . PAF is a biologically active phospholipid whose biological effects include activation of platelets, polymorphonuclear leukocytes, monocytes, and macrophages. PAF increases vascular permeability, decreases cardiac output, induces hypotension, and stimulates uterine contraction.

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SPECIFICATIONS

Catalog Number

160600

Applications

ELISA, FC, ICC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies|Phospholipase|Platelet-activating Factors

Weight

0

Antigen

human PAF amino acids 260-269 (LGFQDSKFHQ){5109,5148,5150}

Isotype

IgG2a

Storage Temp

-20

Shipping Temp

-20

Additional Info

IgG2a . PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-.gamma. have a 2-6 fold increase in PAF receptor expression compared to untreated cells.