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Products PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21)
| Catalogue number: | 160600 |
| Hosts: | Mouse |
| Applications: | ELISA, Flow Cytometry, Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human PAF amino acids 260-269 (LGFQDSKFHQ){5109,5148,5150} |
| P type: | Antibodies|Phospholipase|Platelet-activating Factors |
| Isotype: | IgG2a |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | IgG2a . PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-.gamma. have a 2-6 fold increase in PAF receptor expression compared to untreated cells. |
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