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PARP (Cleaved) Monoclonal Antibody

Cat no: 13557

PARP (Cleaved) Monoclonal Antibody

Antigen: synthetic peptide containing amino acids near the 214/215 cleavage site of human PARP . Isotype: IgG2bk . Host: mouse . Cross Reactivity: (+) human PARP . Application(s): FC (intracellular) and WB . PARP is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa fragment irreversibly binds to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.

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SPECIFICATIONS

Catalog Number

13557

Applications

FC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

synthetic peptide containing amino acids near the 214/215 cleavage site of human PARP

Isotype

IgG2bk

Storage Temp

-20

Shipping Temp

-20

Additional Info

The poly (ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, which activates the base excision repair process. PARP is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa fragment irreversibly binds to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.

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