PCSK9 (human) Polyclonal Antibody

Antigen: synthetic peptide from human PCSK9 amino acids 490-502 . Host: rabbit . Cross Reactivity: (+) human, murine, and rat PCSK9 . Application(s): ICC and WB . PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Several gain of function mutations in the PCSK9 gene are associated with hypercholesterolemia which is characterized by an increase in LDL cholesterol levels.

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SPECIFICATIONS

Catalog Number

10007185

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

synthetic peptide from human PCSK9 amino acids 490-502 (SRSGKRRGERMEA)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low density lipoprotein (LDL) cholesterol levels. PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through acceleration of the degradation of the LDL receptor. PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscle with the highest expression in the liver. Human PCSK9 precursor is 692 amino acid in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein at around 63 kDa in the golgi. Cayman's PCSK9 polyclonal antibody detects mainly the mature form of the protein ranging from 62-66 kDa in tissues and cells such as liver, kidney, and colon cancer cells.