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PCSK9 Polyclonal Antibody

Cat no: 10240

PCSK9 Polyclonal Antibody

Antigen: human recombinant PCSK9 . Host: rabbit . Cross Reactivity: (+) human, rat, and murine PCSK9 . Application(s): ICC and WB . PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Gain-of-function mutations in the PCSK9 gene are associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low-density lipoprotein (LDL) cholesterol levels.

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SPECIFICATIONS

Catalog Number

10240

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human recombinant PCSK9

Storage Temp

-20

Shipping Temp

-20

Additional Info

PCSK9 is a member of the subtilisin serine protease family with an important role in low-density lipoprotein (LDL) metabolism. Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in LDL cholesterol levels. PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through acceleration of the degradation of the LDL receptor. PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscles with the highest expression in the liver. Human PCSK9 precursor is 692 amino acids in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein of 63 kDa in the Golgi.

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