PDS5, Regulator of Cohesion Maintenance, Homolog B (PDS5B, AI646570, Androgen Induced Proliferation Inhibitor, Androgen-induced Prostate Proliferative Shutoff Associated Protein AS3, APRIN, AS3, AW212954, CG008, FLJ23236, KIAA0979, mKIAA0979, RP1-267P19.1

Pds5B is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. It plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64kD cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.\n\nCellular Localization: Nuclear\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

P3126-25H

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

As reported

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Species Crossreactivity: Human and mouse. Other species have not been tested. Reactivity with X. laevis Pds5B is unlikely owing to divergence of sequence between this ortholog and human Pds5B at the site to which the epitope maps.