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Products PGC-1 Polyclonal Antibody
| Catalogue number: | 101707 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human PGC-1.alpha. amino acids 75-90 (NIFEKIDEENEANLLA) |
| P type: | Antibodies|PPAR|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Three peroxisome proliferator-activated receptor .gamma. coactivator 1 (PGC-1) isoforms have been characterized - PGC-1.alpha., PGC-1.beta., and PGC-1-related coactivator (PRC). PGC-1.alpha. and PGC-1.beta. are products of two distinct genes with protein sequences sharing high homology at both the N- and C-terminus. PGC-1.alpha. is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. PGC-1.beta. is also thought to activate oxidative metabolism in tissues, although it does so through a relatively restricted set of transcriptional partners compared to PGC-1.alpha.. PGC-1.alpha. is most abundant in kidney and heart whereas PGC-1.beta. is primarily expressed in heart, brown adipose, and skeletal muscle. Changes in PGC-1.alpha. levels may play a role in metabolic disorders such as type II diabetes and obesity Human PGC-1.alpha. is 798 amino acids in length with a calculated molecular weight of 91 kDa. Cayman's PGC-1 polyclonal antibody detects the protein at around 96 kDa in mouse kidney and liver samples. In human liver microsomes and HEK293 cells, both PGC-1.alpha. and PGC-1.beta. are detected. |
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