PGC-1 Polyclonal Antibody

Antigen: human PGC-1.alpha. amino acids 75-90 . Host: rabbit . Cross-Reactivity: (+) human, mouse, and rat PGC-1.alpha. and PGC-1.beta.; other species not tested . Application(s): WB and IHC (paraffin-embedded tissue sections); other applications not tested . Three PGC-1 isoforms have been characterized - PGC-1(alpha), PGC-1(beta), and PGC-1-related coactivator. PGC-1(alpha) and PGC-1(beta) are inducible transcriptional coactivators for certain nuclear receptors and play a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. Changes in PGC-1 levels may play a role in metabolic disorders such as type II diabetes and obesity.

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SPECIFICATIONS

Catalog Number

101707

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|PPAR|Intracellular Signaling

Weight

0

Antigen

human PGC-1.alpha. amino acids 75-90 (NIFEKIDEENEANLLA)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Three peroxisome proliferator-activated receptor .gamma. coactivator 1 (PGC-1) isoforms have been characterized - PGC-1.alpha., PGC-1.beta., and PGC-1-related coactivator (PRC). PGC-1.alpha. and PGC-1.beta. are products of two distinct genes with protein sequences sharing high homology at both the N- and C-terminus. PGC-1.alpha. is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. PGC-1.beta. is also thought to activate oxidative metabolism in tissues, although it does so through a relatively restricted set of transcriptional partners compared to PGC-1.alpha.. PGC-1.alpha. is most abundant in kidney and heart whereas PGC-1.beta. is primarily expressed in heart, brown adipose, and skeletal muscle. Changes in PGC-1.alpha. levels may play a role in metabolic disorders such as type II diabetes and obesity Human PGC-1.alpha. is 798 amino acids in length with a calculated molecular weight of 91 kDa. Cayman's PGC-1 polyclonal antibody detects the protein at around 96 kDa in mouse kidney and liver samples. In human liver microsomes and HEK293 cells, both PGC-1.alpha. and PGC-1.beta. are detected.