Additional info: |
Phagocytosis is a very important physiological process which is characterized by the ingestion of foreign particles and killing of microorganisms by phagocytic leukocytes (granulocytes, monocytes, and macrophages). It provides a first line of host defense against potential pathogens. Phagocytosis is used as a model of microbe-innate immune interactions, resulting in increased understanding of the consequences of these interactions. Phagocytosis involves a complex series of events including cytoskeletal rearrangement, alterations in membrane trafficking, activation of microbial killing mechanisms, production of pro- and anti-inflammatory cytokines and chemokines, activation of apoptosis, and production of molecules required for efficient antigen presentation to the adaptive immune system. Aberrant phagocytosis has been implicated in several pathological conditions, such as Multiple Sclerosis, Alzheimer |