Phagocytosis Assay Kit (IgG FITC)

Phagocytosis is a physiological process characterized by the ingestion of foreign particles and killing of microorganisms by phagocytic leukocytes (granulocytes, monocytes, and macrophages). Cayman's Phagocytosis Assay (IgG FITC) employs latex beads coated with fluorescently-labeled rabbit-IgG as a probe for the identification of factors regulating the phagocytic process in vitro. The engulfed fluorescent-beads can be detected using a microscope capable of measuring excitation and emission at 485 and 535 nm, respectively, or be analyzed by FC with excitation at 488 nm.

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SPECIFICATIONS

Catalog Number

500290

Form

1 ea

P Type

Assay Kits|Fluorescent Probes

Weight

0

Storage Temp

4

Shipping Temp

4

Additional Info

Phagocytosis is a very important physiological process which is characterized by the ingestion of foreign particles and killing of microorganisms by phagocytic leukocytes (granulocytes, monocytes, and macrophages). It provides a first line of host defense against potential pathogens. Phagocytosis is used as a model of microbe-innate immune interactions, resulting in increased understanding of the consequences of these interactions. Phagocytosis involves a complex series of events including cytoskeletal rearrangement, alterations in membrane trafficking, activation of microbial killing mechanisms, production of pro- and anti-inflammatory cytokines and chemokines, activation of apoptosis, and production of molecules required for efficient antigen presentation to the adaptive immune system. Aberrant phagocytosis has been implicated in several pathological conditions, such as Multiple Sclerosis, Alzheimer