Phosphoinositide 3-Kinase gamma, p110 gamma, His-Tag, Recombinant, Human (PI3K)

PI3K is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3K -/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8 -DCs. In macrophages, the chemokine RANTES/CCL5 activates\nthe small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3K. \n\nPhosphoinositide 3-kinases (PI3Ks) phosphorylate phosphatidylinositols (PIs) at their 3

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SPECIFICATIONS

Catalog Number

P4073-32C

Size

10ug

Form

Supplied as a liquid in 25mM Tris pH 8.0, 50mM sodium chloride, 0.5mM MgCl2, 50% glycerol.

Purity

(same/more than) 95% by SDS-PAGE

References

1.Stoyanov et al. . Science 269:690.(1995) 2.Fuchikami et al. J. Biomol. Scr. 7:441.(2002).3. Leopoldt et al. J. Biol. Chem. 273:7024.(1998)4. Lopez-Ilasaca et al. Science 275:394.(1997) 5. Stoyanova et al. Biochem. J. 324:489. (1997) 6. Foster et al.. J. Cell Science. 116:3037. (2003) 7. Kerchner et al. .J. Biol. Chem. 279:44554.8. Del Prete et al. EMBO J. 23:3505. (2004).9. Weiss-Haljiti et al. J. Biol. Chem. 279:43273. (2004).