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Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K)

Cat no: P4073-32

Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K)

Selective phosphoinositol 3-kinase SH3 ligand\n\nSequence (linear): H2N-Arg-Lys-Leu-Pro-Pro-Arg-Pro-Arg-Arg-OH\n\nPhosphoinositide 3 kinase (PI3K) is a kinase catalyzing the phosphorylation of PI(4,5)P2 at the D3 position of the inositol ring. The resulting product PI(3,4,5)P3 can be recognized by PH domain-containing signaling molecules, including various kinases and their regulators, and activates the corresponding cell signaling pathways, eventually leading to cell growth, survival and cellular movement (1). PI3K is a heterodimer with a p85 regulatory subunit and p110 catalytic subunit. The p85 subunit has two SH2 domains binding to phospho-tyrosine with the consensus motif (Y*XXM) where X denotes any amino acid and Y* is phosphorylated tyrosine. This motif exists in many of the receptor tyrosine kinases and their substrates, such as EGFR, FGFR, IRS-1, BCAP and GAB1 (2,3). The docking of PI3K in the membrane vicinity through p85 recognization of the phosphorylated YXXM in signaling molecules activates the PI3K pathway. Phospho-(Tyr) p85 PI3K Binding Motif Antibody specifically recognizes PI3K binding targets at their phosphorylated YXXM motif, providing a powerful new tool for PI3K binding protein discovery and characterization as well as HTS drug screening for potential regulators.\n\nAmino Acid Analysis: Confirms expected sequence\nPeptide Content: 81.2

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SPECIFICATIONS

Catalog Number

P4073-32

Size

1mg

Form

Supplied as a lyophilized powder.

Purity

~90% by HPLC and MS analysis

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