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Pimecrolimus (Elidel, SDZ-ASM-981, D05480)

Pimecrolimus (Elidel, SDZ-ASM-981, D05480)

Cat no: P4186-66

Supplier: United States Biological
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Pimecrolimus, a rapamycin (sirolimus) derivative, is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type psoriasis, and irritant contact dermatitis. It reduces the production of inflammatory cytokines in T cells and mast cells and inhibits the release of preformed inflammatory mediators from mast cells. Solubility: Soluble in DMSO and ethanol, up to about 25mg/ml. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: P4186-66
Size: 5mg
Form: Supplied as a white powder.
Purity: ~98%
References: 1. Stuetz, A., et al. "Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity." Semin. Cutan. Med. Surg. 20:233-241 (2001). 2. Boone, B., et al. "Topical pimecrolimus in the treatment of vitiligo." Eur. J. Dermatol. 17:55-61 (2007). 3. Hebert, A.A. "Review of pimecrolimus cream 1% for the treatment of mild to moderate atopic dermatitis." Clin. Ther. 28:1972-1982 (2006).

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