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PKC412 (4'-N-Benzoyl Staurosporine, CGP 41251, Midostaurin)

Cat no: P4210-63

PKC412 (4'-N-Benzoyl Staurosporine, CGP 41251, Midostaurin)

The staurosporine analog, PKC412, inhibits a variety of serine/threonine and tyrosine kinases including PKC (IC50=50nM), cyclic AMP-dependent protein kinase (IC50=2.4uM), S6 kinase (IC50=5.0uM), and EGFR (epidermal growth factor receptor) tyrosine-kinase activity (IC50=3.0uM).\n\nSolubility:\nSoluble in DMSO.\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P4210-63

Size

1mg

Form

Supplied as a an off-white to pale yellow powder.

Purity

~99%

References

1. Meyer, T., et al. \"A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity.\" Int. J. Cancer 43:851-856 (1989). 2. Andrejauskas-Buchdunger, E. and Regenass, U. \"Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.\" Cancer Research, 52:5353-5358 (1992). 3. Way, D., et al. \"A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti-ras peptide.\" Cancer Chemother. Pharmacol. 49:429-437 (2002). 4. Bahlis, N.J., et al. \"N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.\" Leuk. Lymphoma 46:899-908 (2005). 5. Si, M.S., et al. \"Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.\" Int. Immunopharmacol. 5:1141-11419 (2005).

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