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Plasminogen Activator Inhibitor Type 1, active, Mouse Assay Kit, BioAssay(TM) (PAI-1)

Cat no: P4256-36

Plasminogen Activator Inhibitor Type 1, active, Mouse Assay Kit, BioAssay(TM) (PAI-1)

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).

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SPECIFICATIONS

Catalog Number

P4256-36

Size

1Kit

References

General references:\n1. Sherman, P.M. et al. (1992) J Biol Chem 267:7588-7595.\n2. McMahon, G. A. et al. (2001) J Biol Chem 276:33964-33968.\n3. Devy, L. et al. (2002) FASEB J 16:147-154.\n4. Schneider, j. et al. (2003) Brit J Canc 88(1):96-101\n5. hou, A. et al. (2003) 10(7):541-544\n6). Rezaie, R. et al. (2001) J Biol Chem 276:15567-15570\n7. Stegansson, S. et al. (1998) J Biol Chem 273:6358-6366

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