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Plasminogen Activator Inhibitor Type 1 P14 Arg, stable mutant, Human (PAI-1)

Cat no: P4256-29A4

Plasminogen Activator Inhibitor Type 1 P14 Arg, stable mutant, Human (PAI-1)

PAI-1 protein has a single substitution at either the P12 or P14 position on the reactive center loop facilitating a conversion of the proteins to a substrate for proteases rather than an inhibitor. Useful for mechanistic studies.\n\nSource:\nPAI-1 from human plasma\n\nSolubility: \n2~5mg/ml\n\nAbsorption: 280nm\n\nMolecular Weight: 43kD\n\nActivity: \nSubstitution at the P14 position on the reactive center loop creates a PAI-1 substrate for proteinases rather than an inhibitor.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P4256-29A4

Size

500ug

Form

Supplied as a liquid in 0.5M sodium phosphate, 0.15M sodium chloride, pH 6.6.

Purity

~98% (SDS-PAGE)

References

1. Lawrence, D. A. et al. (2000) J Biol Chem 275:5839-5844\n2. Audenaert A. M. et al. (1994) J Biol Chem 269:19559-19564

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