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PLCg1, phosphorylated (Tyr783) (1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1, EC=3.1.4.11, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1 PLC1, NCKAP3, PLC-II

Cat no: P4074-42H

PLCg1, phosphorylated (Tyr783) (1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1, EC=3.1.4.11, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1 PLC1, NCKAP3, PLC-II

PLCg1 hydrolyzes phosphatidylinositol-4,5-bisphosphate to generate inositol-1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG), which are implicated in the mobilization of intracellular Ca2+ and protein kinase C activation, respectively. Unlike other PLC isotypes, the protein contain two src homology (SH) 2 domains and one SH3 domain between the X and Y catalytic domains, and these three domains have been implicated in the regulation of cellular proliferation and growth. The protein also has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. Human PLCg

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SPECIFICATIONS

Catalog Number

P4074-42H

Size

50ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Jang Hyun, Choi. et al. Nature Cell Biology. 8:1389-1397 (2006).

Additional Info

Recognizes human PLCg1, phosphorylated at Tyr783. Species Crossreactivity: mouse and rat.

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