Plexin A2 (Plexin-A2, PLXNA2, PLXN2, FLJ11751, FLJ30634, KIAA0463, OCT, Semaphorin Receptor OCT, UNQ209/PRO235)

Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the\nGTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3). Sema6A is also a ligand for Plexin A2. Both Sema6A and Plexin A2 knock-out mice have a granule cell migration defect, where cells remain in the molecular layer. Furthermore,\nPlexin A2 also controls nucleus

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SPECIFICATIONS

Catalog Number

P4271-14

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified

Isotype

IgG

References

(1) Pasterkamp, R.J. and Kolodkin, A.L. (2003) Curr Opin Neurobiol 13, 79-89. (2) Takahashi, T. and Strittmatter, S.M. (2001) Neuron 29, 429-39. (3) Zanata, S.M. et al. (2002) J Neurosci 22, 471-7.\n(4) Renaud, J. et al. (2008) Nat Neurosci 11, 440-9.

Additional Info

Recognizes endogenous levels of total Plexin A2. Species Crossreactivity: mouse, rat.