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Plexin B2 (MM1, PLEXB2, PLXNB2) (APC)

Cat no: 145573

Plexin B2 (MM1, PLEXB2, PLXNB2) (APC)

Plexin B2 is a 240kD type I transmembrane (TM) glycoprotein of the Plexin B family of semaphorin receptors. The mouse Plexin B2 cDNA encodes 1842 amino acids that include a 19 amino acid (aa) signal sequence, a 1182aa extracellular domain (ECD), a 21aa TM domain, and a 620 aa cytoplasmic region. Plexin B2 mRNA is expressed in proliferating cerebellar granule cell progenitors, neuroepithelium, developing neurons, growth plate chondrocytes, tooth bud inner enamel epithelium, glomeruli and mesenchyme of the developing kidney, and in germinal center B lymphocytes when T cell help is present. Plexin B2 is often coexpressed with Plexin B1, and the two may form heterodimers. Genetic deletion of mouse Plexin B2 results in defects in proliferation and migration of cerebellar granule cells, abnormal development of the neural tube and disorganization of the embryonic brain; these defects are not seen when Plexin B1 is deleted. In adults, Plexin B2 is expressed in specialized vascular endothelia, pancreatic islets of Langerhans, and adrenal glands. Plexin B2 serves as a receptor for type 4 semaphorins, especially Sema4C and Sema4G. B Plexins, including Plexin B2, can bind the scatter factor receptors, Met and Ron, and activate them upon semaphorin engagement.\n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nMouse myeloma cells with B cells from Balb/c rats.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at 12 months at 4 degrees C. Freezing allophycocyanin conjugates will result in a substantial loss of activity. Allophycocyaninconjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

145573

Size

100ug

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG2a

Additional Info

Recognizes mouse Plexin B2.

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