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PMM1, Recombinant, Human (PMM 1, PMMH-22, Phosphomannomutase 1, PMMH22)

Cat no: P4296-10


Supplier: United States Biological
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PMM1 (Phosphomannomutase 1) is an enzyme that involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. This enzyme catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. In addition, it may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Source: Recombinant corresponding to aa1-262 of human PMM1 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MAVTAQAARR KERVLCLFDV DGTLTPARQK IDPEVAAFLQ KLRSRVQIGV VGGSDYCKIA EQLGDGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR LPKKRGTFIE FRNGMLNISP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR FSRGGMISFD VFPEGWDKRY CLDSLDQDSF DTIHFFGNET SPGGNDFEIF ADPRTVGHSV VSPQDTVQRC REIFFPETAH EA Molecular Weight: 31.9kD (282aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P4296-10
Size: 50ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 2mM DTT, 100mM sodium chloride, 0.1mM PMSF.
Purity: ~90% (SDS-PAGE).
References: 1. Veiga-da-Cunha M., et al. (2008) J Biol Chem. 283(49):33988-93. 2. Silvaggi N.R., et al. (2006) J. Biol. Chem. 281:14918-14926

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