Podoplanin (Glycoprotein 36, GP36, PA2.26 Antigen, T1-alpha, T1A, Aggrus, PDPN, PSEC0003, PSEC0025)

Expressed at the plasma membrane in epithelia involved in fluid transport, including type I alveolar epithelial cells, choroid plexus, and ciliary epithelium, the specific function of this protein has not been determined but it has been proposed as a marker of lung injury. T1A-2 has a broad tissue distribution with strong expression in lung, placenta and skeletal muscle. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1000\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9104-91M

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Can

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Oakley GJ, Fuhrer K, Seethala RR, Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Modern pathology an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Dec 21(12):1461-9.

Additional Info

Recognizes human PDPN. Species sequence homology: Canine.