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Procalcitonin (Calcitonin Precursor, Calcitonin Related Polypeptide alpha, Calcitonin-related Polypeptide alpha, CALC1, CGRP, CGRP1, CT, Katacalcin, KC, Preprocalcitonin)

Cat no: P9005-27

Procalcitonin (Calcitonin Precursor, Calcitonin Related Polypeptide alpha, Calcitonin-related Polypeptide alpha, CALC1, CGRP, CGRP1, CT, Katacalcin, KC, Preprocalcitonin)

Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13kD. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55aa), calcitonin (32aa) and katacalcin (21aa). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9005-27

Size

200ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human Procalcitonin. Also reacts with Katacalcin.

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