Protein Phosphatase 4 (formerly X) Catalytic Subunit (PPP4C, PP4C, PP4, Protein Phosphatase X, PPX, PP-X, Serine/threonine Protein Phosphatase 4 Catalytic Subunit)

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions. The serine/threonine protein phosphatases (PP) are intimately involved in this process. Protein phosphatase 4C may be involved in microtubule organization. PP4 consists of a catalytic subunit, PPP4C, and a regulatory subunit, PPP4R1, and belongs to the PPP phosphatase family. More specifically it is part of the PP-X subfamily. PP4 is specifically associated with NF-kappa B, p50, c-Rel, and RelA, which are pleiotropic transcription factors that play central roles in the immune and inflammatory responses, as well as apoptosis.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:16,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9107-51H

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum, Rabbit

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Mourtada-Maarabouni M, Williams GT. Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. Biochimica et biophysica acta 2008 Aug 1783 (8): 1490-502.

Additional Info

Recognizes human Ppp4c. Species Crossreactivity: rabbit. Sequence homology: rat, canine.