PSCD2, NT (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2) (APC)

Supplier:

United States Biological

Cat no: 040539-APC

PSCD2, NT (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2) (APC)

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

040539-APC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)\nTorii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)\nWhite, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)\nBouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :\nWu, C., et al. Proteomics 7(11):1775-1785(2007)

Additional Info

Mouse

Alternative Names

CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Applications

ELISA, WB

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Mouse

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