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PTCH1 (Protein Patched Homolog 1, PTC, PTC1, PTCH)

PTCH1 (Protein Patched Homolog 1, PTC, PTC1, PTCH)

Cat no: P3113-82D7

Supplier: United States Biological
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Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 1-3ug/ml, observed in human brain lysates on ~150kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P3113-82D7
Reactivities: Human, Mouse, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Kagawa H, Shino Y, Kobayashi D, Demizu S, Shimada M, Ariga H, Kawahara H. A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1. PLoS One. 2011 Apr 13;6(4):e18638. PMID: 21533246.
Additional info: Recognizes human PTCH. Species Crossreactivity: Mouse. Species sequence homology: Bovine, canine and porcine.

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