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Products PTEN Polyclonal Antibody
| Catalogue number: | 10005059 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human PTEN amino acids 254-270 (KVEFFHKQNKMLKKDKM) |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | PTEN (phosphatase and tensin homology on chromosome 10) dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP3) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. It also interacts with proteins Shc and FAK to promote apoptosis when necessary and to regulate cell division and migration. PTEN is considered a tumor suppressor as loss-of-function mutations in PTEN often result in human cancers including melanoma and prostate carcinoma. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa. Cayman's PTEN polyclonal antibody can be used for western blot (WB) and immunohistochemical analysis (paraffin-embedded tissue sections) on samples from human, chimpanzee, mouse, rat, and dog. It detects the protein from many tissues, as well as from cultured cells such as A431 and HEK293, at 48-50 kDa by WB. |
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