Home  >  Products  >  PTPN6 (Tyrosine-protein Phosphatase Non-receptor Type 6, Protein-tyrosine Phosphatase 1C, PTP-1C, Hematopoietic Cell Protein-tyrosine Phosphatase, SH-PTP1, Protein-tyrosine Phosphatase SHP-1, HCP, PTP1C)
PTPN6 (Tyrosine-protein Phosphatase Non-receptor Type 6, Protein-tyrosine Phosphatase 1C, PTP-1C, Hematopoietic Cell Protein-tyrosine Phosphatase, SH-PTP1, Protein-tyrosine Phosphatase SHP-1, HCP, PTP1C)

PTPN6 (Tyrosine-protein Phosphatase Non-receptor Type 6, Protein-tyrosine Phosphatase 1C, PTP-1C, Hematopoietic Cell Protein-tyrosine Phosphatase, SH-PTP1, Protein-tyrosine Phosphatase SHP-1, HCP, PTP1C)

Cat no: P9109-22D

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, observed in human bone marrow and liver lysates and in mouse and rat spleen and thymus lysates on ~65kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P9109-22D
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med. 2006 May;12(5):549-56. Epub 2006 Apr 16.
Additional info: Recognizes human PTPN6. Species Crossreactivity: Mouse and rat. Species sequence homology: Canine.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave