Home  >  Products  >  PTPRM (Receptor-type Tyrosine-protein Phosphatase mu, Protein-tyrosine Phosphatase mu, R-PTP-mu, PTPRL1)
PTPRM (Receptor-type Tyrosine-protein Phosphatase mu, Protein-tyrosine Phosphatase mu, R-PTP-mu, PTPRL1)

PTPRM (Receptor-type Tyrosine-protein Phosphatase mu, Protein-tyrosine Phosphatase mu, R-PTP-mu, PTPRL1)

Cat no: P9109-40L10

Supplier: United States Biological
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PTP mu, a R2A receptor is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. The Human PTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in Human cancer. PTP mu may be important in responses to pathological conditions associated with the loss of cell-cell interactions in the heart. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P9109-40L10
Reactivities: Human, Mouse, Canine
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY. Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. EMBO J. 2006 Feb 22;25(4):701-12. Epub 2006 Feb 2.
Additional info: Recognizes PTPRM. Species sequence homology: Canine, human and mouse.

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