Purified anti-Chk2

Cat no: 623301

Supplier: BioLegend

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Description
Additional Information

Chk2 (also known as cell cycle checkpoint kinase 2) is a serine/threonine protein kinase containing an FHA domain. There are two reported isoforms of Chk2 (designated A and B) with molecular weights of approximately 60 kD. Chk2 can be modified by phosphorylation. This nuclear protein controls cell cycle checkpoint and inhibits Cdc25C by phosphorylation. Chk2 prevents entry into mitosis and is upregulated by autophosphorylation in response to DNA damage or other agents that cause replication block. Chk2 has been shown to interact with BRCA1, p53, and Cdc25C. The CHK2909 monoclonal antibody has been shown to be useful for Western blotting of the human Chk2 protein.

Catalogue number:	623301
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	50 microl
Clone:	CHK2909
Gene:	11200
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store frozen at -20 C.
Antigen:	Human Chk2 peptide-KLH
Isotype:	Mouse IgG1
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	-20 C
Alternative names:	hCds1, CHEK2, RAD53, Checkpoint kinase 2