Purified anti-CHOP (GADD153)

Cat no: 643602

Supplier: BioLegend

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Description
Additional Information

CHOP (also known as growth arrest and DNA-damage-inducible protein GADD153) is a 27 kD member of the C/EBP transcription factor family containing a basic region involved in DNA binding and a leucine zipper domain. This nuclear protein functions as a dimer to inhibit the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA target sequences. CHOP (GADD153) is induced by endoplasmic-reticulum stress and nutrient deprivation. Phosphorylation by p38-MAP kinase enhances activity of this protein while CK2 phosphorylation decreases activity. CHOP (GADD153) has been shown to interact with c-jun, c-fos, C/EBP, and LAP. The Poly6436 antibody has been shown to be useful for Western blotting of the human CHOP protein.

Catalogue number:	643602
Reactivities:	Human
Hosts:	Rabbit
Applications:	Western Blot
Size:	100 microl
Clone:	Poly6436
Gene:	1649
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store frozen at -20C.
Antigen:	Peptide
Isotype:	Rabbit Polyclonal
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	-20 C
Alternative names:	Growth arrest and DNA-damage-inducible protein GADD153, DNA-damage inducible transcript 3, C/EBP-homologous protein