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Purified anti-Daxx

Purified anti-Daxx

Cat no: 631301

Supplier: BioLegend
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The DAXX-01 monoclonal antibody recognizes human Daxx also known as Death domain-associated protein 6 and EAP1. Daxx is a ubiquitously expressed protein with a predicted molecular weight approximately 81 kD. Daxx binds to both Fas death domain and the apoptosis signal-regulating kinase 1 (ASK1) and promotes Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase(JNK) pathway. Daxx is mainly located in the nucleus as a transcriptional repressor and also located in the cytoplasmic as a proapoptotic signal mediator. The DAXX-01 antibody has been shown to be useful for Western blotting and Immunocytochemistry. Daxx migrated with an apparent molecular weight of approximately 120 kD on SDS-PAGE; this slower than expected migration may reflect the high content of acidic residues in Daxx.
Catalogue number: 631301
Reactivities: Human
Hosts: Mouse
Applications: Immunocytochemistry, Western Blot
Size: 25 microg
Clone: DAXX-1
Gene: 1616
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg antibody per 5 ml antibody dilution buffer for each minigel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Peptide corresponding to amino acids 558-740 of human Daxx.
Isotype: Mouse IgG1
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Death domain-associated protein 6, EAP1
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