Rabbit Anti-FOXA1 monoclonal antibody for WB, ICC/IF, IHC. HNF-1 (? and ?), HNF-3 (?, ? and ?), HNF-4 (? and ?), and HNF-6 compose, in part, a homoeprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3?, HNF-3? and HNF-3? regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3? and HNF-3? have also been shown to be involved in gastrulation events such as body axis formation. HNF-4? and HNF-4? have been shown to be important for early embryo development. HNF-4? is expressed in liver, kidney, pancreas, small intestine, testis and colon; HNF-4? is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3?, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and ?-1 antitrypsin.
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