Rabbit Anti-Human AIM2 monoclonal antibdoy for WB, IP. Absent in melanoma 2 (AIM2) is an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and tumor progression. Expression of AIM2 can inhibit cell growth and tumor formation. Furthermore, the AIM2 gene has a high frequency of mutations associated with microsatellite-unstable colorectal cancers. AIM2 has a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1? and IL-18. Caspase-1 activation is regulated by multi-protein complexes referred to as "inflammasomes". Distinct inflammasome complexes have been described containing NLRP1/NALP1, NLRP3/NALP3, IPAF, and AIM2. The HIN-200 domain of AIM2 is responsible for binding to cytoplasmic double stranded DNA, resulting in caspase-1 activation. This inflammasome complex also involves binding of the pyrin domain of AIM2 to the CARD-domain protein ASC/TMS1, which then interacts directly with caspase-1. As a result, AIM2 has been demonstrated to be an important sensor for a number of different pathogens.
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