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Rabbit Anti-Human MLH1 polyclonal antibody

Rabbit Anti-Human MLH1 polyclonal antibody

Cat no: CABT-L1795

Supplier: Creative Diagnostics
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Rabbit Anti-Human MLH1 polyclonal antibody for IHC-P. MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI) . These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC) . MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Catalogue number: CABT-L1795
Reactivities: Human
Hosts: Rabbit
Conjugates: Unconjugated
Gene: 4292
Target: MLH1
Isotype: IgG
Clonality: Polyclonal
Storage temp: 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

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