Rabbit Anti-Human PLCB1 polyclonal antibody

Rabbit Anti-Human PLCB1 polyclonal antibody for IHC-P. Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ?1, PLC ?2, PLC ?3, PLC ?4, PLC ?1, PLC ?2, PLC ?1, PLC ?2 and PLC ?) with molecular weights ranging from 85 to 150 kDa. PLC ?1, one of the PLC ? isozymes, exists as two immunologically distinguishable proteins of 150 (PLC-?1a) and 140 kDa (PLC ?1b) . The two isoforms encode in two distinct transcripts and generated by alternative splicing of a single gene. PLC ?1a is preferentially expressed in the cytosol, whereas PLC ?1b is predominantly localized in the nuclei. PLC ?1 is a G-protein-dependent phosphodiesterase that hydrolyses phosphatidylinositol 4,5 biphosphate into inositol 1,4,5-triphosphate and diacylglycerol after the stimulation of a variety of neurotransmitter receptors at the cell surface.

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SPECIFICATIONS

Catalog Number

CABT-L1822

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Target

PLCB1

Gene Id

23236

Isotype

IgG

Clonality

Polyclonal

Storage Temp

2-8В°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.