Rabbit Anti-Human PLCB1 polyclonal antibody for IHC-P. Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ?1, PLC ?2, PLC ?3, PLC ?4, PLC ?1, PLC ?2, PLC ?1, PLC ?2 and PLC ?) with molecular weights ranging from 85 to 150 kDa. PLC ?1, one of the PLC ? isozymes, exists as two immunologically distinguishable proteins of 150 (PLC-?1a) and 140 kDa (PLC ?1b) . The two isoforms encode in two distinct transcripts and generated by alternative splicing of a single gene. PLC ?1a is preferentially expressed in the cytosol, whereas PLC ?1b is predominantly localized in the nuclei. PLC ?1 is a G-protein-dependent phosphodiesterase that hydrolyses phosphatidylinositol 4,5 biphosphate into inositol 1,4,5-triphosphate and diacylglycerol after the stimulation of a variety of neurotransmitter receptors at the cell surface.
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