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Rabbit Anti-Human TBX3 monoclonal antibody, clone 33I34M32

Cat no: DCABH-4390

Rabbit Anti-Human TBX3 monoclonal antibody, clone 33I34M32

Rabbit Anti-Human TBX3 monoclonal antibody for ChIP, FC, IF. T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.

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SPECIFICATIONS

Catalog Number

DCABH-4390

Applications

ChIP

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Clone

33I34M32

Target

TBX3

Gene Id

6926

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Store at 4В°C short term. For long term storage, store at -20В°C, avoiding freeze/thaw cycles.

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