Rabbit Anti-Human TIMP1 polyclonal antibody for IHC-P. Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A) , and latent and active forms 92kDa Type IV collagenase (also known as MMP-0 or gelatinase B) . TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.